Mac and Cheese Meatloaf Casserole
Mac and Cheese Meatloaf Casserole is a comforting dish that combines the best of both worlds—savory meatloaf and creamy macaroni and cheese. This recipe is perfect for family dinners or gatherings, providing a unique twist on traditional favorites. Its layers of flavor and texture will leave everyone asking for seconds. Plus, it’s easy to prepare, making it a go-to option for busy weeknights.
Why You’ll Love This Recipe
- Delicious Flavor Combination: The blend of ground beef with rich macaroni and cheese creates a mouthwatering experience.
- Family-Friendly: This dish appeals to all ages, making it great for family meals or potlucks.
- One-Pan Wonder: With everything baked together, cleanup is a breeze, allowing you to enjoy your meal without stress.
- Versatile Ingredients: You can customize the recipe by adding vegetables or different cheeses as per your preference.
- Hearty and Filling: It’s a complete meal in one dish, perfect for satisfying appetites.
Tools and Preparation
To make your cooking experience smoother, gather the necessary tools before starting. Having everything ready ensures a seamless cooking process.
Essential Tools and Equipment
- Mixing bowls
- Ziploc bags
- Rolling pin
- Baking dish (9 x 13 inch)
- Whisk
Importance of Each Tool
- Mixing bowls: Essential for combining ingredients smoothly without making a mess.
- Ziploc bags: Perfect for crushing crackers easily without any spills.
- Whisk: Helps achieve a lump-free mixture when combining liquids and powders.

Ingredients
For the Meatloaf Base
- 1 cup ketchup
- 1 cup Sweet Baby Ray’s Hickory & Brown Sugar barbecue sauce
- 2 lbs lean ground beef
- 30 Ritz Crackers
- 2 oz Lipton onion soup mix
- 2 eggs
For the Macaroni Layer
- 3 cups macaroni noodles
- 2 cups milk
- 10.5 oz condensed cheddar cheese soup
- 1 teaspoon salt
- 1 teaspoon pepper
- 1 tablespoon garlic powder
- 1 tablespoon onion powder
For Topping
- 4 cups shredded mozzarella and cheddar cheese blend
How to Make Mac and Cheese Meatloaf Casserole
Step 1: Preheat the Oven
Preheat your oven to 350°F (175°C) to ensure it’s ready for baking.
Step 2: Prepare the Sauces
In a medium mixing bowl, dump ketchup and barbecue sauce. Stir until well combined, then set aside.
Step 3: Mix the Meatloaf Ingredients
In a large mixing bowl:
1. Add ground beef.
2. Place Ritz crackers in a Ziploc bag and crush them with a rolling pin.
3. Pour the crushed crackers into the bowl with ground beef.
4. Add onion soup mix and eggs.
5. Pour in ½ cup of the ketchup-barbecue mixture.
Use your hands to mix all ingredients thoroughly until fully combined.
Step 4: Bake the Meatloaf
- Transfer the meatloaf mixture into a greased baking dish, pressing it evenly.
- Spread the remaining ketchup-barbecue sauce mixture over the top.
- Bake in preheated oven for 30 minutes.
Step 5: Cook Macaroni Noodles
While the meatloaf bakes:
1. Cook macaroni noodles according to package directions; drain afterward.
Step 6: Prepare Cheese Mixture
In another large mixing bowl:
1. Combine milk and cheddar cheese soup; whisk until smooth.
2. Add salt, pepper, garlic powder, and onion powder; whisk again until well mixed.
3. Stir in cooked macaroni noodles until coated.
Step 7: Assemble Casserole
After baking meatloaf:
1. Carefully pour macaroni mixture over meatloaf; spread evenly.
2. Top with remaining shredded cheese.
Step 8: Final Bake
Return casserole to oven:
– Bake until cheese is melted and slightly brown (approximately 17-20 minutes).
Step 9: Serve
Remove from oven; let sit for a few minutes before slicing and serving warm. Enjoy this hearty Mac and Cheese Meatloaf Casserole!
How to Serve Mac and Cheese Meatloaf Casserole
Serving Mac and Cheese Meatloaf Casserole can elevate your dinner experience. This dish is not only comforting but also versatile, allowing you to pair it with various sides and garnishes to enhance its flavor and presentation.
Classic Garnish
- Chopped Parsley: Sprinkle fresh parsley on top for a pop of color and freshness.
- Sour Cream: A dollop of sour cream can add a creamy tang that complements the casserole well.
Salad Pairing
- Caesar Salad: The crisp romaine and creamy dressing balance the richness of the casserole.
- Coleslaw: A tangy coleslaw adds crunch and contrasts nicely with the hearty flavors.
Bread Options
- Garlic Bread: Serve warm garlic bread for an extra touch of comfort.
- Dinner Rolls: Soft rolls are great for soaking up any leftover sauce.
Vegetable Sides
- Steamed Broccoli: This adds a healthy green component while providing a slight bitterness that pairs well.
- Roasted Brussels Sprouts: Their caramelized exterior enhances the dish’s overall flavor profile.
How to Perfect Mac and Cheese Meatloaf Casserole
To ensure your Mac and Cheese Meatloaf Casserole turns out perfectly every time, consider these helpful tips:
- Use Lean Ground Beef: Opt for lean ground beef to keep your casserole from being overly greasy.
- Crush Crackers Well: Ensure Ritz crackers are finely crushed to create a better texture in the meatloaf.
- Don’t Overmix: Mix the meatloaf ingredients just until combined; overmixing can lead to a dense texture.
- Taste Before Baking: Always taste your meatloaf mixture before baking to adjust seasoning as needed.
- Let It Rest: Allow the casserole to sit for a few minutes after baking; this helps it set for easier slicing.
- Cover While Baking: If the cheese browns too quickly, cover it loosely with foil during the last few minutes of baking.
Best Side Dishes for Mac and Cheese Meatloaf Casserole
Pairing side dishes with your Mac and Cheese Meatloaf Casserole can enhance its flavors. Here are some fantastic options:
- Garlic Mashed Potatoes: Creamy mashed potatoes with garlic make for a comforting side that complements rich flavors.
- Roasted Vegetables: A mix of seasonal veggies roasted with olive oil adds color and nutrients to your meal.
- Corn on the Cob: Sweet corn provides a fun, casual touch that kids love alongside this hearty dish.
- Green Beans Almondine: Fresh green beans sautéed with almonds offer crunch and elegance.
- Potato Wedges: Crispy potato wedges seasoned with herbs are perfect for dipping into any leftover sauce.
- Caprese Salad: A fresh salad made with tomatoes, mozzarella, basil, and balsamic drizzle brightens up the plate beautifully.
Common Mistakes to Avoid
When making Mac and Cheese Meatloaf Casserole, it’s easy to overlook some important details that can affect the final result. Here are some common mistakes to avoid:
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Not measuring ingredients accurately: Precision is key in cooking. Use proper measuring cups and spoons for all ingredients to ensure the right balance of flavors and textures.
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Skipping the mixing step: Mixing the meatloaf mixture thoroughly is crucial. If not combined well, it may lead to uneven cooking or dry spots. Use your hands or a sturdy spoon to mix until everything is evenly blended.
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Overcooking the macaroni: Cooking the macaroni too long will make it mushy. Follow package instructions and aim for al dente, as it will continue cooking in the oven.
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Ignoring resting time: Letting the casserole sit after baking allows it to set properly. Slicing too soon can result in a messy serving. Wait a few minutes before cutting into portions.
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Using stale crackers: Fresh Ritz crackers provide better texture and flavor. Check for freshness before using them in your meatloaf mixture.

Storage & Reheating Instructions
Refrigerator Storage
- Store leftover casserole in an airtight container.
- It will last up to 3–4 days in the refrigerator.
Freezing Mac and Cheese Meatloaf Casserole
- Allow the casserole to cool completely before freezing.
- Wrap tightly with plastic wrap or aluminum foil, or place in a freezer-safe container.
- It can be frozen for up to 2–3 months.
Reheating Mac and Cheese Meatloaf Casserole
- Oven: Preheat to 350°F (175°C). Cover with foil and bake for about 20-25 minutes until heated through.
- Microwave: Place a portion on a microwave-safe plate and heat for 1-2 minutes, stirring halfway through.
- Stovetop: Heat in a skillet over medium heat, stirring occasionally until warmed evenly.
Frequently Asked Questions
If you have questions about making Mac and Cheese Meatloaf Casserole, we’ve got you covered!
What can I substitute for ground beef in Mac and Cheese Meatloaf Casserole?
You can easily substitute ground turkey or chicken for ground beef if you prefer a leaner option. Both work well while maintaining flavor.
Can I add vegetables to my Mac and Cheese Meatloaf Casserole?
Absolutely! Adding diced bell peppers, onions, or spinach can enhance nutrition and flavor. Just sauté them briefly before mixing with the meatloaf.
How do I know when the casserole is fully cooked?
The casserole is done when it reaches an internal temperature of 160°F (70°C) and the cheese on top is melted and slightly browned.
Can I make this recipe ahead of time?
Yes! You can prepare the meatloaf mixture ahead of time, store it in the fridge, and assemble it before baking when you’re ready to serve.
Final Thoughts
Mac and Cheese Meatloaf Casserole is a comforting dish that combines hearty meatloaf with creamy macaroni and cheese. Its versatility allows for various ingredient swaps based on personal preferences or dietary needs. Don’t hesitate to customize it with your favorite cheeses or veggies—this dish is bound to become a family favorite!
Mac and Cheese Meatloaf Casserole
Mac and Cheese Meatloaf Casserole is a delightful comfort food that marries the heartiness of savory meatloaf with the creamy, cheesy goodness of macaroni and cheese. This family-friendly dish is perfect for weeknight dinners or gatherings, offering a unique twist on traditional favorites. With its layers of flavor and texture, it’s sure to become a staple in your home. The best part? It’s simple to prepare, making mealtime stress-free and enjoyable. Experience the delicious combination of ground beef and rich cheeses in this one-pan wonder that everyone will love!
- Prep Time: 20 minutes
- Cook Time: 50 minutes
- Total Time: 1 hour 10 minutes
- Yield: Serves approximately 8
- Category: Main
- Method: Baking
- Cuisine: American
Ingredients
- 2 lbs lean ground beef
- 3 cups macaroni noodles
- 1 cup ketchup
- 1 cup barbecue sauce
- 10.5 oz condensed cheddar cheese soup
- 4 cups shredded mozzarella and cheddar cheese blend
- 2 eggs
- 1 teaspoon salt
- 1 teaspoon pepper
- 1 tablespoon garlic powder
- 1 tablespoon onion powder
- 30 Ritz Crackers
- 2 oz Lipton onion soup mix
- 2 cups milk
Instructions
- Preheat the oven to 350°F (175°C).
- In a bowl, mix ketchup and barbecue sauce; set aside.
- In a large bowl, combine ground beef, crushed Ritz crackers, onion soup mix, eggs, and half of the sauce mixture; mix thoroughly.
- Press the meatloaf mixture into a greased baking dish and top with remaining sauce. Bake for 30 minutes.
- Cook macaroni noodles until al dente; drain.
- In another bowl, whisk together milk and cheddar cheese soup, then add seasonings and cooked macaroni.
- Pour macaroni mixture over the baked meatloaf and top with shredded cheese.
- Return to oven for another 17-20 minutes until cheese is melted.
Nutrition
- Serving Size: 1 slice (210g)
- Calories: 480
- Sugar: 9g
- Sodium: 890mg
- Fat: 25g
- Saturated Fat: 12g
- Unsaturated Fat: 10g
- Trans Fat: 0g
- Carbohydrates: 43g
- Fiber: 2g
- Protein: 32g
- Cholesterol: 110mg
